With the exception of opioid overdose and physical dependence, the effect of most opioids is relatively benign and quickly reversible. However, the use of contaminated needles poses a great danger, which is associated with an increased risk of hepatitis B and hepatitis C, infectious endocarditis and HIV infection; the latter is one of the leading causes of death in injecting drug users and their sexual partners.
Buy Opana Online is one of strongest opioid that have very bad affects if you abuse it. Main effects. Acute digestive disorders – constipation and anorexia – are caused by a decrease in gastrointestinal motility. Chronic digestive disorders in injecting drug users at the stage of addiction are usually due to hepatitis. Stimulation of opiate receptors in the central nervous system can lead to nausea and vomiting (brainstem receptors), dull perception of pain (receptors of the spinal cord, thalamus, near-conductor gray matter), euphoria (receptors of the limbic system), and sedation (receptors of the reticular formation and striatum). Additives contained in “street” drugs can cause a more permanent defeat of the nervous system, including neuropathy, amblyopia, myelopathy and leukoencephalopathy. According to at least one study, the CNS is caused either by opioids themselves, or by additives, or by the use of dirty needles. A single injection of opioids leads to the achievement of LH levels and the subsequent level of testosterone levels; this is a possible cause of a decreased sexual desire, marked by the majority of people with opioid dependence. Other hormonal changes include decreased secretion of TSH and increased secretion of prolactin and STH.
Opioids: an overdose
Intentional (when attempting suicide) or unintentional (with incorrect evaluation of the strength of the drug) taking high doses of opioids leads to intoxication, or overdose syndrome, with the risk of a fatal outcome. Any opioid can cause intoxication, but powerful drugs, such as fentanyl (80-100 times stronger than morphine), are most dangerous.
Typical intoxication, which develops immediately after intravenous injection, is characterized by the following: surface respiration with a frequency of 2-4 per min, miosis (transforming into mydriasis as brain hypoxia develops), bradycardia, hypothermia, no reaction to external stimuli. In the absence of emergency care, cyanosis develops and death occurs due to stopping of breathing and circulation. Findings on autopsy are scant, except for diffuse brain edema. Anaphylactoid reactions to intravenous injection of heroin are also possible, at least in part due to impurities; for such reactions are characterized by inhibition, alveolar edema of the lungs, eosinophilia. There are many opioids that you can buy online. ( mediattics.com )
The primary measure in any overdose is the maintenance of vital functions through ventilation and other emergency measures. A radical method for the treatment of opioid overdose is IV or IM injection of an opioid receptor blocker naloxone in an initial dose of 0.2 mg (0.5 ml from an ampoule per 10 ml) or more. In the absence of the effect, the injection can be repeated after 3-10 minutes. Dose is selected, focusing on the patient’s condition. Since naloxone is only effective for 2-3 hours, the observation period should be at least 24 hours after an overdose of heroin and 72 hours after an overdose of a longer-acting drug such as methadone.